Corollary discharge deficits in schizophrenia

The paper entitled

"Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia" by Lara RöslerKaty Thakkar and colleages has now been accepted for publication in The Journal of Neurophysiology.  

Corollary discharge (CD) refers to “copies” of motor signals sent to sensory areas, allowing prediction of future sensory states. They enable the putative mechanisms supporting the distinction between self- versus externally-generated sensations as well as perceived visual stability across saccadic eye movements.  CD is used to predict the post-saccadic retinal coordinates of visual stimuli—a process called remapping. In the current paper, we found that schizophrenia patients showed remapping disturbances as evidenced by systematic transsaccadic mislocalizations of visual targets. This remapping failure was strongest in patients with more severe psychotic symptoms, consistent with the theoretical link between disturbed CD and the abnormal self-other distinctions that manifest in symptoms like delusions of alien control and auditory hallucinations.

These findings offer clues on how perceptual and motor systems in the brains of individuals with schizophrenia might be disrupted.

Reference

L.Rösler, M. Rolfs, S. van der Stigchel3, S.F.W. Neggers, W. Cahn, R.S. Kahn, K.N. Thakkar (in press). "Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia". J Neurophysiol

 

 

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